I think working in your pajamas can be both a pro and a con. Most days, I'm comfortable and happy wearing whatever--no stress. Inevitably, though, something happens and I find that I have to run out into public looking awful. I'm trying to do better...

One of my cons is constant eating. The desk is too close to the kitchen! I don't remember snacking all day when I was at an office job.

One of the pros is being home to take care of repairs/deliveries/etc. and it makes it easier to deal with kids' doctor and dentist appts. The schedule is so flexible, and that part is great.